Publications

Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
Phillips, Aaron; Miller, Armel; Tigano, Marco; Dubois, Sonia; Crimmins, Hannah; Babin, Loelia; Piganeau, Marion; Brunet, Erika; Sfeir, Agnel                                                                                                                                               2017 Jan 11. pii: S1097-2765(16)30852-8, Mol Cell
 

Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining
Kent, Tatiana; Mateos-Gomez, Pedro A; Sfeir, Agnel; Pomerantz, Richard T
2016 June 17. DOI:10.7554/eLife.13740, eLIFE

Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
Pinzaru, Alexandra M; Hom, Robert; Beal, Angela; Phillips, Aaron F; Ni, Eric; Cardozo, Timothy; Nair, Nidhi; Choi, Jaehyuk; Wuttke, Deborah S; Sfeir, Agnel; and Lazzerini-Denchi, Eros
2016 June 7. DOI:10.1016/j.celrep.2016.43, Cell Reports

Stop pulling my strings - what telomeres taught us about the DNA damage response
Lazzerini-Denchi, Eros and Sfeir, Agnel
2016 May 11. DOI:10.1038/nrm.2016.43, Nature Reviews Molecular Cell Biology

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
Sfeir, Agnel and Symington, Lorraine
2015 Sept 21. DOI:10.1016/j.tibs.2015.08.006, Trends in Biochemical Sciences

Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination   
Mateos-Gomez, Pedro A; Gong, Fade; Nair, Nidhi; Miller, Kyle M; Lazzerini-Denchi, Eros ; Sfeir, Agnel
2015 Feb 12; DOI: 10.1038/nature14157, Nature

Non-telomeric role for Rap1 in regulating metabolism and protecting against obesity
Yeung, Frank; Ramirez, Cristina; Mateos-Gomez, Pedro; Pinzaru, Alexandra; Ceccarini, Giovanni; Kabir, Shaheen; Fernández-Hernando, Carlos; Sfeir, Agnel
2013 Jun 27; 3(6) 1847- 1856, Cell Reports

Telomeres at a glance
Sfeir, Agnel
2012 Sep 15; 125 (pt18):4173-4178, Journal of Cell Science

Removal of shelterin reveals the telomere end-protection problem
Sfeir, Agnel and de Lange, Titia
2012 May 4; 336 (6081):593-597, Science

Rap1-independent telomere attachment and bouquet formation in mammalian meiosis
Scherthan, Harry; Sfeir, Agnel;de Lange, Titia
2011 Apr; 120(2):151-157, Chromosoma

Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions
Kabir, Shaheen; Sfeir, Agnel; de Lange, Titia
2010 Oct 15; 9(20):4061-4067, Cell cycle

Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal
Sfeir, Agnel; Kabir, Shaheen; van Overbeek, Megan; Celli, Giulia B; de Lange, Titia
2010 Mar 26; 327(5973):1657-1661, Science

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication
Sfeir, Agnel; Kosiyatrakul, Settapong T; Hockemeyer, Dirk; MacRae, Sheila L; Karlseder, Jan; Schildkraut, Carl L; de Lange, Titia
2009 Jul 10; 138(1):90-103, Cell

Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells
Zhao, Yong; Sfeir, Agnel J; Zou, Ying; Buseman, Christen M; Chow, Tracy T; Shay, Jerry W; Wright, Woodring E
2009 Aug 7; 138(3):463-475, Cell

The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
Chai, Weihang; Sfeir, Agnel J; Hoshiyama, Hirotoshi; Shay, Jerry W; Wright, Woodring E
2006 Feb; 7(2):225-230, EMBO reports

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
Hockemeyer, Dirk; Sfeir, Agnel J; Shay, Jerry W; Wright, Woodring E; de Lange, Titia
2005 Jul 20; 24(14):2667-2678, EMBO journal

Telomere-end processing the terminal nucleotides of human chromosomes
Sfeir, Agnel J; Chai, Weihang; Shay, Jerry W; Wright, Woodring E
2005 Apr 1; 18(1):131-138, Molecular cell

Fine-tuning the chromosome ends: the last base of human telomeres
Sfeir, Agnel J; Shay, Jerry W; Wright, Woodring E
2005 Nov; 4(11):1467-1470, Cell cycle

Developmental expression patterns and regulation of connexins in the mouse mammary gland: expression of connexin30 in lactogenesis
Talhouk, Rabih S; Elble, Randolph C; Bassam, Rola; Daher, Mariam; Sfeir, Agnel; Mosleh, Lina Abi; El-Khoury, Hilda; Hamoui, Samar; Pauli, Bendicht U; El-Sabban, Marwan E
2005 Jan; 319(1):49-59, Cell & tissue research

Does a sentinel or a subset of short telomeres determine replicative senescence?
Zou, Ying; Sfeir, Agnel; Gryaznov, Sergei M; Shay, Jerry W; Wright, Woodring E
2004 Aug; 15(8):3709-3718, Molecular biology of the cell

Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic
Davies, Brian A; Topp, Justin D; Sfeir, Agnel J; Katzmann, David J; Carney, Darren S; Tall, Gregory G; Friedberg, Andrew S; Deng, Li; Chen, Zhijian; Horazdovsky, Bruce F
2003 May 30; 278(22):19826-19833, Journal of biological chemistry

ECM-induced gap junctional communication enhances mammary epithelial cell differentiation
El-Sabban, Marwan E; Sfeir, Agnel J; Daher, Myriam H; Kalaany, Nada Y; Bassam, Rola A; Talhouk, Rabih S
2003 Sep 1; 116(Pt 17):3531-3541, Journal of cell science